I am working as a Senior Bioinformatician in Integrative Analysis at the COVID-19 Multi-omics Blood ATlas (COMBAT) consortium at the University of Oxford using multi-omics techniques in combination with the cutting-edge bioinformatic approaches and statistical methods to explore the pathogenesis of COVID-19 and stratification of patients as well as inform the treatment strategy based on genomics information.
I hold a B.Sc degree in mathematics from the Shandong University (2006) and a Ph.D degree in bioinformatics from Beijing Institute of Genomics (BIG), Chinese Academy of Science (2011). After graduation, I was appointed as Assistant Professor and Associate Professor in the same institute (2011-2014). During the period in Beijing, I was focusing on the study of genome evolution by means of a large set of genomes from myriad species that span a diversity of taxonomies.
Afterwards, I moved to UK and accepted an appointment as a Research Associate at the Cancer Institute, University College London for nearly two years (2014-2016) where I endeavored to construct several decent comprehensive pipelines for RNA-Seq and ChIP-Seq analyses with their applications on cancer research such as Leukemia study.
After leaving London, I spent two years at Oxford (2016-2018) as a Postdoctoral Research Assistant at the Department of Plant Sciences, University of Oxford where I was working on conducting RNA-Seq analysis to study the mechasims of various groups of Conifer species in response to drought stress in terms of gene expression profiling and sequence variations.
Prior to taking up my current role, I was employed as a Senior Bioinformatics Research Officer at LeedsOmics, University of Leeds where my primary responsibility was to maintain the day-to-day running of LeedsOmics Institute, organise and coordinate LeedsOmics activities such as annual symposiums, research seminar series, training workshops and coding clubs as well as provide the data analysis and training for the researchers in terms of bioinformatics and other cutting-edge omics technologies.
Charlotta Böiers, Simon E. Richardson, Emma Laycock, Alya Zriwil, Virginia A. Turati, John Brown, Jason P. Wray, Dapeng Wang, Chela James, Javier Herrero, Ewa Sitnicka, Stefan Karlsson, Andrew J.H. Smith, Sten Erik W. Jacobsen and Tariq Enver. A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Developmental Cell. 2017 Dec 27. pii: S1534-5807(17)30990-5. PMID: 29290585
Itaru Kato, Yoko Nishinaka, Masahiro Nakamura, Ayse U. Akarca, Akira Niwa, Hiroki Ozawa, Kenichi Yoshida, Makiko Mori, Dapeng Wang, Makiko Morita, Hiroo Ueno, Yusuke Shiozawa, Yuichi Shiraishi, Satoru Miyano, Rajeev Gupta, Katsutsugu Umeda, Kenichiro Watanabe, Katsuyoshi Koh, Souichi Adachi, Toshio Heike, Megumu K. Saito, Masashi Sanada, Seishi Ogawa, Teresa Marafioti, Akira Watanabe, Tatsutoshi Nakahata and Tariq Enver. Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA. Blood. 2017 Jun 8;129(23):3126-3129. PMID: 28424164
Dapeng Wang. hppRNA – A Snakemake-based handy parameter-free pipeline for RNA-Seq analysis of numerous samples. Briefings In Bioinformatics. 2017 Jan 17. pii: bbw143. PMID: 28096075
Dapeng Wang, Jiayue Xu and Jun Yu. KGCAK: A K-mer based database for genome-wide phylogeny and complexity evaluation. Biology Direct 2015, 10:53. PMID: 26376976
Dapeng Wang and Jun Yu. LCGserver: a webserver for exploring evolutionary trajectory of gene orders in a large number of genomes. OMICS: A Journal of Integrative Biology. 2015 Sep;19(9):574-7. PMID: 26258441
Dapeng Wang and Jun Yu. Plastid-LCGbase: a collection of evolutionarily conserved plastid-associated gene pairs. Nucleic Acids Research. 2015 Jan;43(Database issue):D990-5. PMID: 25378306
Cristina Pina, Jose Teles, Cristina Fugazza, Gill May, Dapeng Wang, Yanping Guo, Shamit Soneji, John Brown, Patrik Eden, Mattias Ohlsson, Carsten Peterson and Tariq Enver. Single-cell network analysis identifies ddit3 as a nodal lineage regulator in hematopoiesis. Cell Reports 2015 Jun 16;11(10):1503-10. PMID: 26051941
Bin Xie, Dapeng Wang, Yong Duan, Jun Yu, and Hongxing Lei. Functional networking of human divergently paired genes. PLoS ONE. 2013, 8(10): e78896. PMID: 24205343
Yunbo Li, Dapeng Wang, Lei Wang, Jinhai Yu, Danhua Du, Ye Chen, Peng Gao, Duen-Mei Wang, Jun Yu, Feng Zhang, and Shuanglin Fu. Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients. PLoS ONE. 2013, 8(2): e57168. PMID: 23451178
Dapeng Wang, Yan Xia, Xinna Li, Lixia Hou and Jun Yu. The Rice Genome Knowledgebase (RGKbase): an annotation database for rice comparative genomics and evolutionary biology. Nucleic Acids Research. 2013; 41: D1199-D1205.PMID: 23193278
Lei Wang, Xiaowei Zhang, Linlin Pan, Wanfei Liu, Dapeng Wang, Guangyu Zhang, Yuxin Yin, An Yin, ShangangJia, Xiaoguang Yu, Gaoyuan Sun, Songnian Hu, Ibrahim S. Al-Mssallem, and Jun Yu. A Large-scale gene discovery for the red palm weevil Rhynchophorus ferrugineus (Coleoptera: Curculionidae). Insect Science 2013, 20: 689–702. PMID: 23955844
Dapeng Wang, Yao Su, Xumin Wang, Hongxing Lei and Jun Yu. Transposon-Derived and Satellite-Derived Repetitive Sequences Play Distinct Functional Roles in Mammalian Intron Size Expansion. Evolutionary Bioinformatics 2012:8 301-319. PMID: 22807622
Dapeng Wang, Yubin Zhang, Zhonghua Fan, Guiming Liu and Jun Yu. LCGbase: A Comprehensive Database for Lineage-Based Co-regulated Genes. Evolutionary Bioinformatics 2012:8 39-46. PMID: 22267903
Dapeng Wang and Jun Yu. Both size and GC-content of minimal introns are selected in human populations. PLoS ONE 2011, 6(3): e17945. PMID: 21437290
Dapeng Wang, Fei Liu, Lei Wang, Shi Huang and Jun Yu. Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes. Biology Direct 2011, 6:13. PMID: 21342519
Yan-Hui Zhao, Da-Peng Wang, Li-Li Zhang, Feng Zhang, Duen-Mei Wang and Wei-Yuan Zhang. Genomic expression profiles of blood and placenta reveal significant immune-related pathways and categories in Chinese women with gestational diabetes mellitus. Diabetic Medicine 2011, 28: 237–246. PMID: 21219437
Feng Liu, Dapeng Wang, Jianjun Fu, Gaoyuan Sun, Yubang Shen, Lingli Dong, Bing Zhang, Songnian Hu, and Jiale Li. Identification of immune-relevant genes by expressed sequence tag analysis of head kidney from grass carp (Ctenopharyngodon idella). Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2010, 5(2):116-23. PMID: 20403773
Dapeng Wang, Yubin Zhang, Zhang Zhang, Jiang Zhu, and Jun Yu. KaKs Calculator 2.0: a toolkit of incorperating gamma methods and sliding window strategies. Genomics Proteomics & Bioinformatics 2010, 8(1): 77-80. PMID: 20451164
Jiang Zhu, Fuhong He, Dapeng Wang, Kan Liu, Dawei Huang, Jingfa Xiao, Jiayan Wu, Songnian Hu, and Jun Yu. A novel role for minimal introns: routing mRNAs to the cytosol. PLoS ONE 2010, 5(4): e10144. PMID: 20419085
Dapeng Wang, Song Zhang, Fuhong He, Jiang Zhu, Songnian Hu, and Jun Yu. How do variable substitution rates influence the calculations of Ka and Ks? Genomics Proteomics & Bioinformatics 2009, 7(3): 116-127. PMID: 19944384
Da-Peng Wang, Hao-Lei Wan, Song Zhang, and Jun Yu. Gamma-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates. Biology Direct 2009, 4:20. PMID: 19531225